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pentobarbital will reduce the level or impact of gefitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will minimize the extent or impact of lonafarnib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib is often a sensitive CYP3A4 substrate. Coadministration with strong or average CYP3A4